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Recruitment took place at two locations: the Department of Psychiatry and Psychotherapy of the University Hospital Erlangen (n = 14) and the Frankenalb Clinic for Psychiatry, Psychotherapy and Psychosomatic Medicine in Engelthal (n = 42).Both ceramide concentrations and apoptosis rate were decreased by simultaneous addition of the functional ASM inhibitor desipramine . single suche Recklinghausen Ethanol-induced ceramide accumulation was also observed in primary rat neurons, human and mouse neuroblastoma cells .Similarly, the activity of plasmatic S-ASM dropped remarkably by about 50% from day 0 to day 10 of physical withdrawal to levels that were still above those of healthy controls .In the search for peripheral biomarkers as surrogates for central physiological as well as psychological changes, the activity of S-ASM would thus be a promising candidate.
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Furthermore we provide the first data for associations of S-ASM activities with psychometric variables.Patients were recruited as part of the Franconian Alcoholism Research Study (FARS-IV) at the University of Erlangen-Nuremberg during the years 2009/2010 according to the protocol established in previous studies .Cellular and plasmatic ASM activities are increased in male alcohol dependent patients and decrease during physical withdrawal.Methods: Here, we analyzed the time course of ASM in male and also female acutely intoxicated patients during alcohol withdrawal and compared the activity levels to those under long-term maintenance treatment.In a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity, ASM activity was increased and associated with an elevated ceramide content in tissues .
Another ASM inhibitor, imipramine, blocked the ethanol-induced ASM activation and ceramide generation and resulted in amelioration of hepatic steatosis in ethanol-fed mice .Liver biopsies from patients with alcoholic hepatitis exhibited 2-3-fold higher expression levels of ASM and endoplasmatic reticulum stress markers at the m RNA level than samples from control subjects .We have previously observed an altered peripheral ASM activity in alcohol dependent patients: L-ASM levels were increased in acutely intoxicated individuals' blood mononuclear cells and decreased during withdrawal . If your browser does not accept cookies, you cannot view this site.There are many reasons why a cookie could not be set correctly.